Scientist (Downstream Processing)
Esco Lifesciences Group is Singapore’s most globalized
life sciences company, with annual revenues close to SGD 200M and global
operations in over 42 locations and 26 direct countries across North America,
Europe, Asia, Oceania.
Esco Aster Pte Ltd is an affiliate of Esco
Lifesciences Group and was first incorporated in 2017.
Esco Aster is a contract research development and
manufacturing organization founded and deeply rooted by scientists enabling
fellow scientists to translate their bench work into commercially available
products at affordable prices.
Our
scientific work is in emerging and frontier biology utilizing cells as a final
product or deriving products from cells which often we use cells as the factory
to derive our target product.
Our
first commercial breakthrough success is Esco Aster is commercially first in
class being first in the world to be certified for cultivated/cell-based meat
to FSSC 22000 and by a competent food regulatory body.
We
are first in the region to operate an end-to-end integrated full cell line
creation/immortalization or engineered cell line, cell culture process
development, analytical development for stem cells and exosomes with full cGMP
Capabilities from Drug Substance and small-scale fill & finish for final
Cell Therapy Product.
The work we do creates a remarkable and lasting impact
on our world. We offer you an opportunity to be part of this exciting journey
to own your career and firsthand exposure to new emerging modalities supporting
translational sciences.
Join us as we redefine BioSolutions for One World and
One Health for the current and future generations to come.
Esco Aster.
One World Biosolutions for One Health.
Physical/Mental Requirements/Work Environment
- Ability to read, analyze and interpret
scientific data and publications.
- Ability to author or review protocols,
technical reports and technology transfer documents.
- Ability to author or review standard
operating procedures and other related documents.
- Ability to define problems, collect
data, establish facts, and draw conclusions.
- Ability to focus.
- Repetitive motions due to certain
laboratory techniques.
- Ability to adapt and keep up with rapid
changes in a fluid and dynamic environment as this is a rapidly evolving
space.
- Good understanding of cGMP and GDP
requirement and practices.
- Able to don in the cleanroom gowning and
understand Aseptic Behavior requirements.
Report to: Selected candidate will report to CEO and others as assigned.
- Work in the CDMO services as a part of the process team to develop processes for downstream unit operations for adherent cells (MSCs, iPSCs, Fibroblast, Epithelial cells, Vero, Hek293t) and derivatives (e.g. exosomes, nanovesicles, viral vectors, secreted viruses, mitochondria) as well as suspension cells for cultivated meat (mainly continuous centrifugation).
- Design, plan, execute, and supervise experimental programs.
- Analyze and interpret experiment data to draw scientific conclusions.
- Perform wet lab and /or clinical trial material activities related to downstream unit operations and associated analytics.
- Support and train subordinates on downstream techniques and operations.
- Author or review protocols, technical reports, technology transfer and training documents with scientifically supported conclusions and recommendations.
- Author or review standard operating procedures, instrument operating procedures and other lab related documents.
- Assess and implement new processes and technologies in development scale, ultimately adapting to manufacturing operations.
- Record and document data promptly and accurately maintaining data integrity.
- Assist in non-routine lab duties and administrative activities including, and not limited to procurement, vendor assessment, people management, equipment maintenance, equipment calibration etc.
- Support validation activities for new equipment as required.
- The successful candidate will have a Bachelor or Master’s degree or doctorate in Biological Sciences/(Bio)Chemical Engineering/Biological Engineering/Chemistry or related disciplines.
- At least 3-5 years’ relevant experience in a life-sciences or related laboratory working with the downstream purification of stem cells/exosomes.
- Experience in filtration (NFF and TFF) unit operations and bioprocess integration.
- Knowledge of protein and molecular analyses, e.g., Western blot, qPCR, ELISA, flow cytometry etc.
- Knowledge of technical or commercial operations in the manufacture of biological molecules is desirable.
- Proficient in MS office- MS word, MS excel, PowerPoint.
- Take initiatives, self-starter, research oriented, and able to work with minimum supervision.
- Possess good communication and documentation skills.
- Can contribute individually, as well as work efficiently in a dynamic team environment.
Apply now by submitting a Cover Letter and CV to [email protected].