Contract Fermentation Services & Process Dev't

Overview

Fermentation is a process where microorganisms are grown under controlled conditions with an aim of optimizing the growth of the organism for production of a target microbial product.

Continuous Fermentation involves the development of microorganisms under a controlled environment where culture media are constantly eliminated and replaced in a bioreactor for the manufacturing of the desired bioproduct.

Esco Aster provides fermentation capabilities from Diagnostic Antigen / Antibodies, Peptides, Intermediates (Viral Vectors), Therapeutics, to Food Ingredients / Products for Cellular Agriculture / Alternative Proteins in both continuous liquid and solid-state fermentation.

Capabilities

Strain Development

Large-scale Contract Fermentation (5-100L)

Fermentation can then be scaled up to 50-100 (50,000-100,000 liters) tons in a purpose built dedicated site with our Design, Build and Operate contract services

Recombinant DNA Technology

Fermentation Process Validation

Microbial Fermentation

Fed-batch
Semi-continuous
Continuous
Solid-state

Fermentation Process Optimization for Expression / Production of :

Recombinant Proteins
Peptides
Enzymes
Active Pharmaceutical Ingredients (APIs)
Biomass Generation
Cellular Agriculture
Alternative Proteins

Our Solutions

Diagnostics

PCR Enzymes
Plasmid amplification for cell culture-expressed antigen/antibodies
Microbial expression of antigen/antibodies

Fermented Peptides

Commonly used for in-vivo diagnostics especially for imaging. Learn more on our Specialty Diagnostics here
Learn more about our Cosmeceuticals here
Learn more about our Biopeptides here

Fermented Enzymes

Enzyme replacement therapy
Enzymes used in cell culture and bioprocess
Enzymes used for industrial biotech

Plasmid Amplification for Intermediates

(for genetically-engineered cell therapy, gene therapy, vaccines, oncolytic viruses applications)

Lentivirus
Retrovirus
Adenovirus
Adeno-Associated Virus
pDNA
Learn more about our Plasmid Manufacturing Services here

Growth Factors

Commonly used in cell culture media for expressing therapeutics/biologics, cosmeceuticals or cellular agriculture media
Some peptides are also synthesized using flow chemistry

Therapeutics

Plasmid amplification for biologics, sub unit vaccines
Fermentation: monoclonal antibodies, recombinant proteins

Vaccines

Plasmid amplification for adherent-based vero vaccines (e.g dengue, oncolytic viruses)
Nucleic acid vaccines (mRNA/RNA/DNA)
Fermentation vaccines

Food Ingredients / Products

Animal-free enzymes (e.g. pepsin)
Microbial/Plant-based proteins
Microbial/Plant-based food flavorings

Continuous Fermentation