Continuous Fermentation

Overview

Fermentation is a process where microorganisms are grown under controlled conditions with an aim of optimizing the growth of the organism for production of a target microbial product.

Continuous Fermentation involves the development of microorganisms under a controlled environment where culture media are constantly eliminated and replaced in a bioreactor for the manufacturing of the desired bioproduct.

Esco Aster provides fermentation capabilities from Diagnostic Antigen / Antibodies, Peptides, Intermediates (Viral Vectors), Therapeutics, to Food Ingredients / Products for Cellular Agriculture / Alternative Proteins in both continuous liquid and solid-state fermentation.

Capabilities

Strain Development

Large-scale Contract Fermentation (5-100L)

Fermentation can then be scaled up to 50-100 (50,000-100,000 liters) tons in a purpose built dedicated site with our Design, Build and Operate contract services

Recombinant DNA Technology

Fermentation Process Validation

Microbial Fermentation

  • Fed-batch
  • Semi-continuous
  • Continuous
  • Solid-state

Fermentation Process Optimization for Expression / Production of :

  • Recombinant Proteins
  • Peptides
  • Enzymes
  • Active Pharmaceutical Ingredients (APIs)
  • Biomass Generation
  • Cellular Agriculture
  • Alternative Proteins

Our Solutions

Diagnostics
  • PCR Enzymes
  • Plasmid amplification for cell culture-expressed antigen/antibodies
  • Microbial expression of antigen/antibodies
Diagnostics
Fermented Peptides
  • Commonly used for in-vivo diagnostics especially for imaging. Learn more on our Specialty Diagnostics here
  • Learn more about our Cosmeceuticals here
  • Learn more about our Biopeptides here
Fermented Peptides
Fermented Enzymes
  • Enzyme replacement therapy
  • Enzymes used in cell culture and bioprocess
  • Enzymes used for industrial biotech
Fermented Enzymes
Plasmid Amplification for Intermediates

(for genetically-engineered cell therapy, gene therapy, vaccines, oncolytic viruses applications)

  • Lentivirus
  • Retrovirus
  • Adenovirus
  • Adeno-Associated Virus
  • pDNA
  • Learn more about our Plasmid Manufacturing Services here
Plasmid Amplification for Intermediates
Growth Factors
  • Commonly used in cell culture media for expressing therapeutics/biologics, cosmeceuticals or cellular agriculture media
  • Some peptides are also synthesized using flow chemistry
Growth Factors
Therapeutics
  • Plasmid amplification for biologics, sub unit vaccines
  • Fermentation: monoclonal antibodies, recombinant proteins
Therapeutics
Vaccines
  • Plasmid amplification for adherent-based vero vaccines (e.g dengue, oncolytic viruses)
  • Nucleic acid vaccines (mRNA/RNA/DNA)
  • Fermentation vaccines
Vaccines
Food Ingredients / Products
  • Animal-free enzymes (e.g. pepsin)
  • Microbial/Plant-based proteins
  • Microbial/Plant-based food flavorings
Food Ingredients / Products