In the realm of science and medicine, peptides have emerged as a fascinating and versatile class of molecules with wide variety of applications. These small chain of amino acids play a crucial role in various physiological processes not only in human body but also, for animals as well.
Peptides represent a captivating area of scientific exploration with remarkable potential for therapeutic, functional, diagnostic, industrial, and food applications.
Esco Aster manufactures the highest quality peptide products and are widely used in following applications:
Aquaculture and fisheries contribute a growing share of nutrition for the global population. Considered as the fastest growing food animal sector globally, aquatic animals provide 20% of animal protein to the human diet for over 40% of the world, with consumption growth outpacing rates for all other sources of animal protein combined.
The rapid growth in animal protein production has been facilitated by a transition from expensive to intensive farming, which in terrestrial food animal sectors has historically been accompanied by the increasing use of antimicrobials which exerts selective pressures driving antimicrobial resistance. This in turn have potential implications for food security and nutrition.
In the continuous pursuit for alternatives, Antimicrobial Peptides (AMPs) represent a critical part of the host immune system and have been documented to have immunomodulatory activity. Increasing research evidence suggests that in contrast to antibiotics, AMPs exert broad-spectrum antibacterial activity in a manner that reduces bacterial acquisition of resistance genes.
The European Union banned the use of animal growth promoters in animal feed in 2006. Thus, a new antibacterial strategy is needed. Many AMPs have the potential to be used in poultry, swine, and ruminants breeding and aquaculture because of the following reasons:
For example, swine intestine antimicrobial peptides (SIAMP) has a good effect on the treatment of infectious bronchitis virus (IBV) in chickens. By adding swine gut intestinal antimicrobial peptides, broilers showed higher average daily gain and feed efficiency under chronic heat conditions.
Moreover, frog caerin 1.1., European sea bass dicentracin and NK-lysine peptides (NKLPs) have good inhibitory effects on Nodavirus, Septicemia hemorrhagic virus, Infectious pancreatic necrosis virus and Spring viremia carp virus, which are devastating to fish farming. The AMP in soybean meal fermented by Bacillus subtilis E20 effectively inhibits Vibrio parahaemolyticus and V. alginolyticus and enhances the resistance level of Litopenaeus vannamei against V. parahaemolyticus when added to feeds.
The global challenge to prevent fungal spoilage and mycotoxin contamination on food and feed requires the development of new antifungal strategies. Antimicrobial Peptides (AMPs) and proteins with antifungal activity are gaining much interest as natural antifungal compounds due to their properties such as:
Given AMPs’ multistep mode of action, the development of fungal resistance to AMPs is presumed to be slow or delayed compared to conventional fungicides. Moreover, they have important biological functions other than antifungal activity, it includes “anti-mycotoxin biosynthesis activity, which opens novel aspects for their future use in agriculture and food industry to fight mycotoxin contamination.
We are capable of synthesizing broad range of therapeutic/functional peptides / proteins through:
Through our in-house technologies, we have the ability to increase their half-lives through: