The other very important application of Tide Motion® Bioreactors is in stem cell culture. Existing commercial and late stage allogeneic mesenchymal stem cell or mesenchymal stromal or medicinal signaling cells are often manufactured using either 2D multilayer planar culture ware with optional automated harvesting or 3D microcarriers which are occasionally dissolvable but often not.
Esco Aster provides Tide Motion® method as an alternative to linearly aid in scaling up MSCs for allogeneic cell therapy. The Tide Motion platform can also be used to produce allogeneic cell sources for gene- edited cell therapy as such CAR-T, CAR-NK as well as other immune cells that are derived from iPSCs or hESCs. Thus, other adherent packed bed bioreactors, hyperflasks, hyperstacks can easily be replaced by the Tide Motion® platform to provide viral vectors, for gene therapy and oncolytic viruses or cancer vaccines which often utilize HEK 293T and other adherent cell lines as expression platforms.