Therapeutic Peptides

We understand that peptide development is filled with challenges. Due to hydrophilicity, peptides exhibit limited ability to cross physiological barriers and are confronted with efficient hepatic and renal clearance. Also, once inside the systemic circulation, peptides typically have rather short half lives due to aggressive degradation by multiple digestive proteases. These aspects have led to difficult administration routes which resulted to low patient compliance

Synthetic Services

We are capable of synthesizing broad range of therapeutic peptides / proteins through:

  • A novel continuous flow approach with the latest technology
  • Conventional Solid Phase Peptide
  • Synthesis/Liquid Phase Peptide Synthesis (SPPS/LPPS)
  • Combo Technology
  • Fermentation
  • Recombinant DNA methodology

Comprehensive Peptide Modifications

Through our in-house technologies, we have the ability to increase their half-lives through:

  • Polyethylene Glycol (PEG) Modification
    • Linkers
    • Spacers
  • N-terminal and Side-chain Modification
    • PEGylation
    • Acetylation (lipopeptides)
    • Formylation
  • Peptide Stapling
    • Ring Closing Metathesis (RCM)
    • Thioether Formation
  • Peptide Macrolyzation

A World of Possibilities with Peptides

Esco Aster manufactures the highest quality peptide products and are widely used in the following applications:

Possibilities with Peptides