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Senior Scientist, Sequencing

The Opportunity

Esco Lifesciences Group provides enabling technologies, products and services to the life sciences and healthcare industries, supporting academic research and scientific discoveries, clinical practice, as well as biopharmaceutical R&D and manufacturing. Headquartered in Singapore, Esco has an extensive sales network in over 100 countries, direct sales and service offices in over 24 countries, 8 manufacturing and R&D hubs in the US, Europe, the UK, China, Singapore, Indonesia, and over 1500 employees worldwide.

Esco is poised to benefit from the sustained growth of the healthcare and biopharma industries in Asia and globally. Esco has achieved market leadership in China, and globally, in multiple categories within some of the fastest-growing segments — with China being its largest and fastest growing market. As a Singapore-headquartered company, Esco is a nexus of East and West, bridging technologies, products and talent across the world, with global operations spanning the US, Europe and Asia.

Who we’re looking for

Physical/Mental Requirements/Work Environment

  • Ability to read, analyze and interpret scientific data and publications.
  • Ability to author or review protocols, technical reports and technology transfer documents.
  • Ability to author or review standard operating procedures and other related documents.
  • Ability to define problems, collect data, establish facts, and draw conclusions.
  • Ability to focus.
  • Repetitive motions due to certain laboratory techniques.
  • Ability to adapt and keep up with rapid changes in a fluid and dynamic environment as this is a rapidly evolving space.

The Scope

The position will be on a project studying the evolution of cancer genomes during early steps in carcinogenesis, with the long-term aim to develop personalized peptide therapeutics. Esco Aster is currently looking for a Senior Scientist to support our existing and future sequencing projects. The ideal candidates should be well-equipped with molecular biology techniques and have a passion for implementing new technologies into the sequencing workflow to improve accuracy and efficiency.

Job Responsibilities

  • Set up, plan and establish WES/WGS/RNA-/Ribo-sequencing workflows.
  • Perform sample nucleic acid isolation, QC, prepare sequencing libraries, and perform high throughput sequencing.
  • Set up SOPs and ensure proper documentation of all processes.
  • Ensure all sequencing data are of well quality prior to data analysis.
  • Troubleshoot sequencing workflow and improve processes whenever necessary.
  • Interact with data scientist and evaluate bioinformatics output.
  • Maintain lab equipment & documentation in accordance with quality requirements.

Requirements

  • The successful candidate will have a PhD in Cell/Molecular/Cancer Biology, Biochemistry, Immunology, Biological/Chemical Engineering, or related disciplines.
  • At least 10 years lab experience in sequencing, molecular biology, cancer biology or related fields.
  • Deep understanding of subject areas to include cancer biology, clinical oncology, or immunology with a strong background in tumor biology and application of NGS solutions to clinical samples.
  • Extensive hands-on experience with NGS technologies is a must.
  • Expertise in processing and analysis of next-generation sequencing data.
  • Familiar with lab-based and computational methodologies and platforms used for generating and analyzing high-content NGS data, including nucleus RNA-seq and others.
  • Ability to analyse biological data using programming language (eg MATLab, Python, R) is a plus.
  • Expertise with a wide range of materials used in genomics, including DNA, RNA, and FFPE materials .
  • Working knowledge of DNA hybridization, ligation, fragmentation, endpolishing, PCR, automation using robotics, Agilent Bioanalyzer, nanodrop, qPCR, sterile/clean room techniques, and sample and process tracking is also required.
  • Possess a thoughtful and meticulous approach to experimental design and execution.
  • Bring scientific rigor and creativity to problem solving.
  • Ability to collaborate and work effectively as part of a team in a dynamic environment
  • Have a positive, proactive, can-do attitude.
  • Possess troubleshooting skills and ability to exercise sound judgment and make decisions based on accurate and timely analyses.
  • Good verbal communication, interpersonal and team skills.

Preferences

  • Demonstrated ability to translate Bioinformatics analysis results into new biological insights, propose next experiments, and enable program decisions.
  • Possess hands-on programming skills: especially R, Python, Unix & cluster computing environment.
  • Experience with data visualization tools (Plotly, RStudio Connect/Shiny, Dash, Spotfire, etc).

Apply now by submitting a Cover Letter and CV to [email protected].