Join Our
Team

The Opportunity

Who we’re looking for

Physical/Mental Requirements/Work Environment

• Ability to read, analyze and interpret scientific data and publications.
• Ability to author or review protocols, technical reports and technology transfer documents.
• Ability to author or review standard operating procedures and other related documents.
• Ability to define problems, collect data, establish facts, and draw conclusions.
• Ability to focus.
• Repetitive motions due to certain laboratory techniques.
• Ability to adapt and keep up with rapid changes in a fluid and dynamic environment as this is a rapidly evolving space.

The Scope

The position will be on a project studying the evolution of cancer genomes during early steps in carcinogenesis, with the long-term aim to develop personalized peptide therapeutics. Esco Aster is currently looking for a Senior Scientist to support our existing and future sequencing projects. The ideal candidates should be well-equipped with molecular biology techniques and have a passion for implementing new technologies into the sequencing workflow to improve accuracy and efficiency.

Job Responsibilities

• Set up, plan and establish WES/WGS/RNA-/Ribo-sequencing workflows.
• Perform sample nucleic acid isolation, QC, prepare sequencing libraries, and perform high throughput sequencing.
• Set up SOPs and ensure proper documentation of all processes.
• Ensure all sequencing data are of well quality prior to data analysis.
• Troubleshoot sequencing workflow and improve processes whenever necessary.
• Interact with data scientist and evaluate bioinformatics output.
• Maintain lab equipment & documentation in accordance with quality requirements.

Requirements

• The successful candidate will have a PhD in Cell/Molecular/Cancer Biology, Biochemistry, Immunology, Biological/Chemical Engineering, or related disciplines.
• At least 10 years lab experience in sequencing, molecular biology, cancer biology or related fields.
• Deep understanding of subject areas to include cancer biology, clinical oncology, or immunology with a strong background in tumor biology and application of NGS solutions to clinical samples.
• Extensive hands-on experience with NGS technologies is a must.
• Expertise in processing and analysis of next-generation sequencing data.
• Familiar with lab-based and computational methodologies and platforms used for generating and analyzing high-content NGS data, including nucleus RNA-seq and others.
• Ability to analyse biological data using programming language (eg MATLab, Python, R) is a plus.
• Expertise with a wide range of materials used in genomics, including DNA, RNA, and FFPE materials .
• Working knowledge of DNA hybridization, ligation, fragmentation, endpolishing, PCR, automation using robotics, Agilent Bioanalyzer, nanodrop, qPCR, sterile/clean room techniques, and sample and process tracking is also required.
• Possess a thoughtful and meticulous approach to experimental design and execution.
• Bring scientific rigor and creativity to problem solving.
• Ability to collaborate and work effectively as part of a team in a dynamic environment
• Have a positive, proactive, can-do attitude.
• Possess troubleshooting skills and ability to exercise sound judgment and make decisions based on accurate and timely analyses.
• Good verbal communication, interpersonal and team skills.

Preferences

• Demonstrated ability to translate Bioinformatics analysis results into new biological insights, propose next experiments, and enable program decisions.
• Possess hands-on programming skills: especially R, Python, Unix & cluster computing environment.
• Experience with data visualization tools (Plotly, RStudio Connect/Shiny, Dash, Spotfire, etc).

Apply now by submitting a Cover Letter and CV to [email protected].