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Research Officer / Assistant (Viral Vectors)

The Opportunity

Esco Lifesciences Group provides enabling technologies, products and services to the life sciences and healthcare industries, supporting academic research and scientific discoveries, clinical practice, as well as biopharmaceutical R&D and manufacturing. Headquartered in Singapore, Esco has an extensive sales network in over 100 countries, direct sales and service offices in over 24 countries, 8 manufacturing and R&D hubs in the US, Europe, the UK, China, Singapore, Indonesia, and over 1500 employees worldwide

Esco is poised to benefit from the sustained growth of the healthcare and biopharma industries in Asia and globally. Esco has achieved market leadership in China, and globally, in multiple categories within some of the fastest-growing segments — with China being its largest and fastest growing market. As a Singapore-headquartered company, Esco is a nexus of East and West, bridging technologies, products and talent across the world, with global operations spanning the US, Europe and Asia.

Who we’re looking for

Physical/Mental Requirements/Work Environment

  • Ability to read, analyze and interpret scientific data and publications.
  • Ability to author or review protocols, technical reports and technology transfer documents.
  • Ability to author or review standard operating procedures and other related documents.
  • Ability to define problems, collect data, establish facts, and draw conclusions.
  • Ability to focus.
  • Repetitive motions due to certain laboratory techniques.
  • Ability to adapt and keep up with rapid changes in a fluid and dynamic environment as this is a rapidly evolving space

The Scope

Esco Aster as a CDMO, we are looking for a research officer/assistant who is innovative, passionate and energetic with expertise in AAV viral vector production and associated optimization and quality control processes.

Esco Aster is seeking to hire Research Officers/Assistants to participate in this collaborative project. The role would include a variety of responsibilities in a team setting and the team will be taking part in process development and GLP/GMP compliant manufacturing thereby bringing next-generation, lifesaving, critical and transformative gene therapies to patients with debilitating disorders.

Primary work location: Ayer Rajah Crescent, Singapore

Reporting to: Lead Scientist 

Responsibilities (but are not limited to)

  • Manufacturing of recombinant viral vectors – AAV, LV, RV in adherent and suspension HEK293 cells
  • Purification of recombinant viral vectors using various chromatography techniques and/or ultracentrifugation
  • Quality control of recombinant viral vectors using qPCR, dPCR, DLS, FACS
  • Keeping detailed and accurate records of experiments, data, and analysis to ensure data integrity and protect associated intellectual property.
  • Performing basic lab management duties, including maintenance of lab equipment, timely ordering of consumables and supplies, reagent preparation etc

Requirements

  • Minimum Bachelor’s degree in Life Sciences or related fields with at least 2 years hands on cell culture and work experience.
  • Proficiency in tissue culture techniques, particularly using HEK293(T), including transfection and/or electroporation
  • Experience with recombinant viral vectors such as AAV, LV and RV is a plus.
  • Familiarity with molecular biology techniques, including standard recombinant DNA technology/ cloning, performing studies that would include DNA/RNA isolation and analyses with qPCR, digital PCR, protein assessments with Western blot, ELISA, immunolabelling (IHC, IF, ICC), and flow cytometry.
  • Previous exposure to chromatography techniques either analytical or preparative would be advantageous.
  • Ability to independently design and execute experiments following defined protocols and processes and produce highly accurate and reproducible data.
  • Experience with good laboratory practices (GLP) will be an advantage.
  • Proficiency with MS Office, FlowJo, SnapGene, Prism, and other commonly used software
  • Keen interest in pursuing a highly focused project and working efficiently to meet milestones.
  • Comfortable to undertake routine and SOP-directed lab work.
  • Be proactive, co-operative, and willing to work in small team environment
  • Have strong verbal, written, and interpersonal communication skills
  • Detail Oriented and have high standards in documentation.
  • Good time management and pro-active attitude.
  • Good communication skills and able to work in a team.

Apply now by submitting a Cover Letter and CV to [email protected].

For other job openings in Esco Lifesciences Group within the respective geographies, kindly refer to corporate website.