Adenoviruses can cause a wide range of illnesses in humans, such as respiratory tract infections. To make adenovirus an effective and safe tool for gene delivery, two genes involved in viral replication and modulating host immune response are deleted. Once inside the cell, recombinant adenovirus remains episomal and does not integrate into the host genome. Adenovirus is a popular choice for gene delivery applications primarily because of its large packaging capacity, high transgene expression, and ability to infect most cell types.
As a CRO, CRDMO, Esco Aster provides viral vector production services in varying grades--research/preclinical, clinical, and commercial, respectively. Choosing and producing the best viral vectors to be used for your desired applications can be difficult, but we are here to help every step of the way!
Research / Preclinical Grade