Esco Aster News & Events


January 29, 2018

Esco Aster, a leading independent contract development and manufacturing organization underpinned by its patent Tide Motion bioreactor technology, has signed a research collaboration agreement with Department of Biomedical Engineering, National University of Singapore (NUS) to develop a miniaturised 3D organoid bioreactor system that can recapitulate the early stages of brain development, potentially representing a powerful in-vitro system for modelling brain diseases and enabling future scalable clinical applications.

Under the terms of the agreement, both parties will jointly develop an economical and compact bioreactor to immobilise 3D spheroids and organoids in the Tide Motion technology that leverage the unique capabilities of Esco’s scalable bioreactors and continuous bioprocessing platform. This miniaturised 3D organoid bioreactor system shall provide the first proof-of-concept study that carry great potential for scalable cultures targeting at neurodegenerating disorders.

“At NUS scientists have developed an innovative self-assembled organisation approach to cerebral organoids in the lab. Combined with our Tide Motion technology, we hope the collaboration can be expanded to include other fields, such as disease modelling studies and pathology for developing therapeutics.”

Xiangliang Lin, Esco Aster's Chief Executive Officer. 

Esco Aster has continued expanding their bioreactors based advanced manufacturing solutions and processes, and enabling future applications to bringing quality research tools to the scientific and clinical markets in the emerging field of organoid technologies.


Esco Aster Pte Ltd

21 Changi South Street 1

Singapore 486777

T: +65 6542 0833

E: [email protected]


Esco Aster CDMO Laboratory

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Singapore 139951


About Tide Motion Bioreactors

Tide motion pertains to the oscillation of culture medium into and out of the matrix vessel that intermittently exposes the cells to aeration and nutrition. The upward oscillation exposes the cells to nutrition, while the downward oscillation exposes the cells to aeration and at the same time washes away products and wastes. This gentle oscillation produces no air bubbles and causes very minimal shear stress, which are both detrimental to the cells. View a range of products at 


About Esco Aster

Esco Aster is a contract development and manufacturing organisation (CDMO) focusing on offering vaccine-, cell- and gene-therapy development and biomanufacturing services using its proprietary TideMotion technology, bioprocessing and bioengineering equipment. 

Esco Aster aims to be a best-in-class cGMP CDMO, enabling the production of larger quantities of biologics materials needed for preclinical toxicology studies, clinical trials and eventual commercialisation, thus accelerating the transition of novel technologies from laboratory to patients in need. For more information on Esco Aster, please visit