Chemical process development plays a key role on the scale-up and manufacture of APIs. Among the several parameters that control process development, cost efficiency is a key parameter which can be achieved by careful design/redesign of synthetic routes coupled with effective work-up procedure and purification protocols.
Continous Flow process is emerging as one of the mostly amenable, enabling technologies which utilizes appropriately designed small reactors in which streams of substrates and reagents can be mixed to react in a highly controlled, more safer and reproducible environment.
Validation and effective modification of synthetic routes for operational ease and cost efficiency. Team is well-versed in retrosynthetic approaches and redesign strategies.
Process safety assesment to identify potenially hazordous reactions and replace potentially hazardous reagents with environmentally benign reagents and establish milder reaction conditions.
Appropriate Standardized modules to handle different reactions and multiple batch sizes
Diversification of API synthesis using common key intermediates
Development and optimization of synthetic routes suitable for flow chemistry
Establishment of a safer alternate way for hazardous reactions
Streamlining and automation of multistep reaction sequences of APIs
Peptide synthesis, Intermediates for API and compound libraries