A list of journal articles that have used VacciXcell products for various applications.
Drugmand, J., Havelange, N., Osumba, S., Bosco, F., Debras, F., Collignon, F., . . . Castillo, J. (n.d.). New Disposable Fixed-Bed Bioreactor for Cell Culture and Virus Production Based on a Proprietary Agitation and Aeration System. Cells and Culture, 151-155.
(Link: http://link.springer.com/chapter/10.1007/978-90-481-3419-9_24)
Drugmand, J., J.-F., J., Agathos, S., & Schneider, Y. (n.d.). Growth of Mammalian and Lepidopteran Cells on BioNOC® II Disks, a Novel Macroporous Microcarrier. Cell Technology for Cell Products, 781-784.
(Link: http://link.springer.com/chapter/10.1007%2F978-1-4020-5476-1_143)
Akiyama, M., Nakayama, D., Takeda, S., Kokame, K., Takagi, J., & Miyata, T. (n.d.). Crystal structure and enzymatic activity of an ADAMTS-13 mutant with the East Asian-specific P475S polymorphism. J Thromb Haemost Journal of Thrombosis and Haemostasis, 1399-1406.
(Link: http://www.ncbi.nlm.nih.gov/pubmed/23621748)
Asaoka, Y., Tanaka, T., Tsumoto, K., Tomita, M., & Ide, T. (n.d.). Efficient expression of recombinant soluble human FcγRI in mammalian cells and its characterization. Protein Expression and Purification, 155-161.
(Link: http://www.sciencedirect.com/science/article/pii/S1046592811003524)
Brown, A., Mcsharry, J., Adams, J., Kulawy, R., Barnard, R., Newhard, W., . . . Drusano, G. (2011). Pharmacodynamic Analysis of a Serine Protease Inhibitor, MK-4519, against Hepatitis C Virus Using a Novel In Vitro Pharmacodynamic System. Antimicrobial Agents and Chemotherapy, 1170-1181.
(Link: http://www.ncbi.nlm.nih.gov/pubmed/22155837)
Chen, Y., Wu, J., Wang, K., Chiang, Y., Lai, C., Chung, Y., & Hu, Y. (n.d.). Baculovirus-mediated production of HDV-like particles in BHK cells using a novel oscillating bioreactor. Journal of Biotechnology, 135-147.
(Link: http://www.ncbi.nlm.nih.gov/pubmed/15951042)
Drugmand, J., J.-F., J., Agathos, S., & Schneider, Y. (n.d.). Growth of Mammalian and Lepidopteran Cells on BioNOC® II Disks, a Novel Macroporous Microcarrier. Cell Technology for Cell Products, 781-784.
(Link: http://link.springer.com/chapter/10.1007%2F978-1-4020-5476-1_143)
Hammonds, J., Chen, X., Zhang, X., Lee, F., & Spearman, P. (n.d.). Advances in methods for the production, purification, and characterization of HIV-1 Gag–Env pseudovirion vaccines. Vaccine, 8036-8048.
(Link: http://www.ncbi.nlm.nih.gov/pubmed/17936444)
Haredy, A., Takenaka, N., Yamada, H., Sakoda, Y., Okamatsu, M., Yamamoto, N., . . . Okamoto, S. (2013). An MDCK Cell Culture-Derived Formalin-Inactivated Influenza Virus Whole-Virion Vaccine from an Influenza Virus Library Confers Cross-Protective Immunity by Intranasal Administration in Mice. Clinical and Vaccine Immunology, 998-1007.
(Link: http://www.ncbi.nlm.nih.gov/pubmed/23637045)
Haredy, A., Yamada, H., Sakoda, Y., Okamatsu, M., Yamamoto, N., Omasa, T., . . . Yamanishi, K. (2014). Neuraminidase gene homology contributes to the protective activity of influenza vaccines prepared from the influenza virus library. Journal of General Virology, 2365-2371.
(Link: http://www.ncbi.nlm.nih.gov/pubmed/25053564)
Ho, L., Greene, C., Schmidt, A., & Huang, L. (n.d.). Cultivation of HEK 293 cell line and production of a member of the superfamily of G-protein coupled receptors for drug discovery applications using a highly efficient novel bioreactor. Cytotechnology, 117-123.
(Link: http://www.ncbi.nlm.nih.gov/pubmed/19003249)
Hu, Y., Lu, J., & Chung, Y. (n.d.). High-density cultivation of insect cells and production of recombinant baculovirus using a novel oscillating bioreactor. Cytotechnology, 145-153.
(Link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3449450/)
Huang, K., Lo, W., Chung, Y., Lai, Y., Chen, C., Chou, S., & Hu, Y. (n.d.). Combination of Baculovirus-Mediated Gene Delivery and Packed-Bed Reactor for Scalable Production of Adeno-Associated Virus. Human Gene Therapy, 1161-1170.
(Link: http://www.ncbi.nlm.nih.gov/pubmed/17944574)
Jepson, S., Vought, B., Gross, C., Gan, L., Austen, D., Frantz, J., . . . Krauss, R. (2012). LINGO-1, a Transmembrane Signaling Protein, Inhibits Oligodendrocyte Differentiation and Myelination through Intercellular Self-interactions. Journal of Biological Chemistry, 22184-22195.
(Link: http://www.ncbi.nlm.nih.gov/pubmed/22514275)
Kato, K., Nishimasu, H., Mihara, E., Ishitani, R., Takagi, J., Aoki, J., & Nureki, O. (2012). Expression, purification, crystallization and preliminary X-ray crystallographic analysis of Enpp1. Acta Cryst Sect F Acta Crystallogr F Struct Biol Cryst Commun Acta Cryst Sect F Struct Biol Cryst Commun Acta Cryst F Struct Biol Cryst Commun Acta Cryst F Acta Crystallographica Section F Structural Biology and Crystallization Communications Acta Crystal, 778-782.
(Link: http://www.ncbi.nlm.nih.gov/pubmed/22750863)
Lu, J., Chung, Y., Chan, Z., & Hu, Y. (n.d.). A Novel Oscillating Bioreactor BelloCell: Implications for Insect Cell Culture and Recombinant Protein Production. Biotechnology Letters Biotechnol Lett, 1059-1065.
(Link: http://link.springer.com/article/10.1007%2Fs10529-005-8450-3)
Mcsharry, J., Singer, D., Kulawy, R., Brown, A., & Drusano, G. (n.d.). Use of the BelloCell System to Determine the Optimal Dose of Ribavirin to Inhibit the Expression of an HCV Replicon in 2209-23 Cells. Antiviral Research.
Tabata, S., Nampo, M., Mihara, E., Tamura-Kawakami, K., Fujii, I., & Takagi, J. (n.d.). A rapid screening method for cell lines producing singly-tagged recombinant proteins using the “TARGET tag” system. Journal of Proteomics, 1777-1785.
(Link: http://www.ncbi.nlm.nih.gov/pubmed/20566373)
Toriniwa, H., & Komiya, T. (n.d.). Japanese encephalitis virus production in Vero cells with serum-free medium using a novel oscillating bioreactor. Biologicals, 221-226.
(Link: http://www.ncbi.nlm.nih.gov/pubmed/17400474)
Yasui, N., Mihara, E., Nampo, M., Tamura-Kawakami, K., Unno, H., Matsumoto, K., & Takagi, J. (n.d.). Detection of endogenous LRP6 expressed on human cells by monoclonal antibodies specific for the native conformation. Journal of Immunological Methods, 153-160.
VacciXcell has to date sold over 600 CelCradle Single Use Bioreactors and have a growing portfolio of clients. Due to non-disclosure agreements (NDA) only limited information may be provided of our clients.
Some of these clients are:
| Country | Cell Line | Virus Strain | Cell Density | Virus Titer |
| USA | CEF | WEE | 4 x107 | 109pfu/ml |
| Taiwan | BHK-21 | Pseudorabies | 2.35x107 | 108.8 TCID50/ml |
| Taiwan | HEK-293 | Adenovirus | 3.5 x107 | 108pfu/ml |
| Taiwan | SF-9 | Baculovirus | 6x107 | 109pfu/ml |
Kaiser, P., Werner, M., Jérôme, V., Hübner, H., Buchholz, R., & Freitag, R. (2014). Cell retention by encapsulation for the cultivation of Jurkat cells in fixed and fluidized bed reactors. Biotechnol. Bioeng. Biotechnology and Bioengineering, 2571-2579.
(Link: http://onlinelibrary.wiley.com/doi/10.1002/bit.25304/abstract)
Palmer, C., Anzinger, J., Zhou, J., Gouillou, M., Landay, A., Jaworowski, A., . . . Crowe, S. (2014). Glucose Transporter 1-Expressing Proinflammatory Monocytes Are Elevated in Combination Antiretroviral Therapy-Treated and Untreated HIV Subjects. The Journal of Immunology, 5595-5603.
(Link: http://www.ncbi.nlm.nih.gov/pubmed/25367121)
Sagare, A., Bell, R., Srivastava, A., Sengillo, J., Singh, I., Nishida, Y., . . . Zlokovic, B. (2013). A Lipoprotein Receptor Cluster IV Mutant Preferentially Binds Amyloid- and Regulates Its Clearance from the Mouse Brain. Journal of Biological Chemistry, 15154-15166.
(Link: http://www.ncbi.nlm.nih.gov/pubmed/23580652)
Roop, J. I., Chang, K. C., & Brem, R. B. (2016). Polygenic evolution of a sugar specialization trade-off in yeast. Nature, 530(7590), 336-339.
(Link: www.nature.com/)