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Join us for the world we are making, redefining medicine for the current and future generations to come.

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Compensation
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Are you a seasoned professional looking
for your next challenge? Be one of us!

Bioprocess Scientist (Dx and Therapeutics Mabs/Recombinant proteins)

The Opportunity

Esco Lifesciences Group is Singapore’s most globalized life sciences company, with annual revenues close to 200M and global operations in over 20 countries across North America, Europe and Asia. At Esco, we embrace innovation and take calculated risks to address unmet needs, all while building a leading life sciences ecosystem that will benefit the communities that we operate in. As a rapidly growing global business (growing at high double digits annually) and expanding worldwide through M&A, we empower you with the opportunities to excel and drive impact.

At Esco Aster, we are a contract development and manufacturing organization founded and deeply rooted by scientists enabling fellow scientists to translate their bench work into life-saving diagnostics, medicines, therapies, cosmeceuticals, cellular agriculture, at affordable prices for their country self-sufficiency.

The work we do creates a lasting remarkable impact on healthcare. Join us for the world we are making as we redefine medicine for current and future generations to come.

Esco Aster. One World. One Health.

Primary Job Location: Ayer Rajah Crescent, One North. Esco Aster PD (Process Development)/clinical ops, Singapore. Some travel as needed to GMP site in changi, Singapore.

Report To: CEO with external consultants/advisors that have >60 years of collective antibody engineering and expression experience in various Singapore IHLs.

Responsibilities

  • Scaling up of Diagnostic and Therapeutic Mabs/Recombinant proteins. Projects on hand are for covid-19 Dx, Covid19 sub-unit vaccine, Covid-19 Therapeutics. Dengue Dx/Therapeutics.
    Scaling up is from 1L shake flasks into 10L->50L->200L->500L->2,000L
  • Creation of RCB using manual/ automated clone picking.
  • Process transfer of commercial biologics expressed in CHO/Hybridoma and other adherent cell lines from Roller Bottles, Hollow Fiber bioreactors and other 2D planar culture into Esco Aster adherent Tide Motion. E.g. Cho/Epo.
  • Support creation of MCBs from collaborators final Clone high producing RCB.
  • Work closely with external collaborators utilizing in silico modelling for upwards scaling.
  • Work closely with speciality Diagnostics team to produce antigens/antibodies as active ingredient for coating onto lateral flow strips, Elisa, CLIA platforms.
  • Work closely with gene therapy/gene editing/fermentation team for vector and plasmid design/upscaling.
  • Work closely with internal quality team and external regulators to ensure DS meets international standards.

Authority

  • Build and lead a team of bioprocess scientists.

Deputies

  • Research officers / Research assistants.

Requirements

  • PhD graduate with publications in Mabs/Recombinant proteins with at least 6 years post doc/industrial experience.
  • Experience in Mammalian cell culture in adherent and suspension Cho / Hek 293T/Hek 239S/ Insect Cells.
  • Experience in high cell density high antibody with minimum yield of 1 grams/L or higher.
  • Experience in transient transfection platforms typically using Hek 293Expi/ChoExpi or equivalent.
  • Experience in antibody characterization, analytics and binding affinity using biacore/Attana or equivalent.

Preferred Experience(s)

  • Knowledgeable in large scale perfusion single use suspension culture in 50L to 200L with mininum 2 grams/L high yield.
  • Downstream Processing (DSP) knowledge in purification of Mabs/Recombinant proteins.
  • Past patent experience on matter of composition of Mabs/Recombinant proteins.
  • Past patent experience on process patents of expressing mabs/recombinant proteins.
  • Cell line gene editing for high producing clones.
  • Omics experience in analytics of mammalian cell culture.
  • Spent media analysis for optimizing media.
  • Upscaling from microreactors such as ambr.

Apply now by submitting a Cover Letter and CV to [email protected].

If no preferred experience, on the job training will be provided by Esco Aster in collaboration with vendors.

We regret to inform that only shortlisted applicants will be contacted for an interview. During this COVID-19 pandemic, we are prioritizing recruitment of Singaporeans / PRs, existing E-Pass, S-Pass and Work Permit Holders due to imposed travel restrictions.

For other job openings in Esco Lifesciences Group within the respective geographies, kindly refer to corporate website.